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{{STRUCTURE_4ezw|  PDB=4ezw  |  SCENE=  }}
===Crystal structure of the substrate binding domain of E.coli DnaK in complex with the designer peptide NRLLLTG===
{{ABSTRACT_PUBMED_23562829}}


==Function==
==Crystal structure of the substrate binding domain of E.coli DnaK in complex with the designer peptide NRLLLTG==
[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]  
<StructureSection load='4ezw' size='340' side='right'caption='[[4ezw]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ezw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezw OCA], [https://pdbe.org/4ezw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezw RCSB], [https://www.ebi.ac.uk/pdbsum/4ezw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]


==About this Structure==
==See Also==
[[4ezw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZW OCA].
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
[[Category: Escherichia coli k-12]]
__TOC__
[[Category: Straeter, N.]]
</StructureSection>
[[Category: Zahn, M.]]
[[Category: Escherichia coli K-12]]
[[Category: Chaperone]]
[[Category: Large Structures]]
[[Category: Chaperone-peptide binding protein complex]]
[[Category: Straeter N]]
[[Category: Zahn M]]
Retrieved from "https://proteopedia.org/4ezw"