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{{STRUCTURE_2zrw|  PDB=2zrw  |  SCENE=  }}
===Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with FMN and IPP.===
{{ABSTRACT_PUBMED_19158086}}


==Function==
==Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with FMN and IPP.==
[[http://www.uniprot.org/uniprot/IDI2_SULSH IDI2_SULSH]] Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity).  
<StructureSection load='2zrw' size='340' side='right'caption='[[2zrw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2zrw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_shibatae Saccharolobus shibatae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZRW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPR:ISOPENTYL+PYROPHOSPHATE'>IPR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zrw OCA], [https://pdbe.org/2zrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zrw RCSB], [https://www.ebi.ac.uk/pdbsum/2zrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zrw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDI2_SACSH IDI2_SACSH] Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).[HAMAP-Rule:MF_00354]<ref>PMID:19158086</ref> <ref>PMID:22158896</ref> <ref>PMID:22505674</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zrw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zrw ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[2zrw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_shibatae Sulfolobus shibatae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRW OCA].
*[[Isopentenyl-diphosphate delta-isomerase|Isopentenyl-diphosphate delta-isomerase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019158086</ref><references group="xtra"/><references/>
__TOC__
[[Category: Isopentenyl-diphosphate Delta-isomerase]]
</StructureSection>
[[Category: Sulfolobus shibatae]]
[[Category: Large Structures]]
[[Category: Hemmi, H.]]
[[Category: Saccharolobus shibatae]]
[[Category: Ikeda, Y.]]
[[Category: Hemmi H]]
[[Category: Kusunoki, M.]]
[[Category: Ikeda Y]]
[[Category: Nakayama, T.]]
[[Category: Kusunoki M]]
[[Category: Nishino, T.]]
[[Category: Nakayama T]]
[[Category: Sekiguchi, S.]]
[[Category: Nishino T]]
[[Category: Unno, H.]]
[[Category: Sekiguchi S]]
[[Category: Yamashita, S.]]
[[Category: Unno H]]
[[Category: Yoshida, N.]]
[[Category: Yamashita S]]
[[Category: Yoshimura, T.]]
[[Category: Yoshida N]]
[[Category: Flavoprotein]]
[[Category: Yoshimura T]]
[[Category: Fmn]]
[[Category: Idi]]
[[Category: Ipp]]
[[Category: Isomerase]]
[[Category: Isopentenyl diphosphate isomerase]]
[[Category: Isoprene biosynthesis]]
[[Category: Nadp]]
[[Category: Type 2]]
Retrieved from "https://proteopedia.org/2zrw"