2m7c: Difference between revisions

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'''Unreleased structure'''


The entry 2m7c is ON HOLD
==Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple==
<StructureSection load='2m7c' size='340' side='right'caption='[[2m7c]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2m7c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7c OCA], [https://pdbe.org/2m7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7c RCSB], [https://www.ebi.ac.uk/pdbsum/2m7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7c ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Trp-cage, at 20 residues in length, is generally acknowledged as the smallest fully protein-like folding motif. Linking the termini by a two-residue unit and excising one residue affords circularly permuted sequences that adopt the same structure. This represents the first successful circular permutation of any fold of less than 50-residue length. As was observed for the original topology, a hydrophobic staple near the chain termini is required for enhanced fold stability.


Authors: Byrne, A., Andersen, N.H., Kier, B.L.
Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple.,Byrne A, Kier BL, Williams DV, Scian M, Andersen NH RSC Adv. 2013 Nov 21;2013(43). doi: 10.1039/C3RA43674H. PMID:24376912<ref>PMID:24376912</ref>


Description: Trp-cage Circular Permutant
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2m7c" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Andersen NH]]
[[Category: Byrne A]]
[[Category: Kier BL]]
Retrieved from "https://proteopedia.org/2m7c"