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{{STRUCTURE_3nvx|  PDB=3nvx  |  SCENE=  }}
===Molecular mechanism of guidance cue recognition===
{{ABSTRACT_PUBMED_20727575}}


==Function==
==Molecular mechanism of guidance cue recognition==
[[http://www.uniprot.org/uniprot/VA39_VACCC VA39_VACCC]] Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of host plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection (By similarity).  
<StructureSection load='3nvx' size='340' side='right'caption='[[3nvx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Copenhagen Vaccinia virus Copenhagen]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NVX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvx OCA], [https://pdbe.org/3nvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nvx RCSB], [https://www.ebi.ac.uk/pdbsum/3nvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nvx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SEMA_VACCC SEMA_VACCC] Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of host plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/3nvx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nvx ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Repulsive signaling by Semaphorins and Plexins is crucial for the development and homeostasis of the nervous, immune, and cardiovascular systems. Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic secreted by smallpox virus. We report the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1. Both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers, in which the Semaphorin and PlexinC1 beta propellers interact in an edge-on, orthogonal orientation. Both binding interfaces are dominated by the insertion of the Semaphorin's 4c-4d loop into a deep groove in blade 3 of the PlexinC1 propeller. A39R appears to achieve Sema7A mimicry by preserving key Plexin-binding determinants seen in the mammalian Sema7A complex that have evolved to achieve higher affinity binding to the host-derived PlexinC1. The complex structures support a conserved Semaphorin-Plexin recognition mode and suggest that Plexins are activated by dimerization.


==About this Structure==
Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.,Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X Cell. 2010 Sep 3;142(5):749-61. Epub 2010 Aug 19. PMID:20727575<ref>PMID:20727575</ref>
[[3nvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVX OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:020727575</ref><references group="xtra"/><references/>
</div>
[[Category: Vaccinia virus]]
<div class="pdbe-citations 3nvx" style="background-color:#fffaf0;"></div>
[[Category: Chen, X.]]
 
[[Category: Focia, P.]]
==See Also==
[[Category: Garcia, C.]]
*[[Semaphorin 3D structures|Semaphorin 3D structures]]
[[Category: He, X.]]
== References ==
[[Category: Juo, Z.]]
<references/>
[[Category: Liu, H.]]
__TOC__
[[Category: Shim, A.]]
</StructureSection>
[[Category: Beta-propeller]]
[[Category: Large Structures]]
[[Category: Viral protein]]
[[Category: Vaccinia virus Copenhagen]]
[[Category: Chen X]]
[[Category: Focia P]]
[[Category: Garcia C]]
[[Category: He X]]
[[Category: Juo Z]]
[[Category: Liu H]]
[[Category: Shim A]]
Retrieved from "https://proteopedia.org/3nvx"