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{{STRUCTURE_3o4r|  PDB=3o4r  |  SCENE=  }}
===Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4)===


==Function==
==Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4)==
[[http://www.uniprot.org/uniprot/DHRS4_HUMAN DHRS4_HUMAN]] Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).  
<StructureSection load='3o4r' size='340' side='right'caption='[[3o4r]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3o4r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4R FirstGlance]. <br>
[[3o4r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4R OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4r OCA], [https://pdbe.org/3o4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4r RCSB], [https://www.ebi.ac.uk/pdbsum/3o4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHRS4_HUMAN DHRS4_HUMAN] Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/3o4r_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o4r ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bhatia, C.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bhatia C]]
[[Category: Delft, F von.]]
[[Category: Bountra C]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Krojer, T.]]
[[Category: Krojer T]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Ugochukwu E]]
[[Category: Ugochukwu, E.]]
[[Category: Vollmar M]]
[[Category: Vollmar, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Yue WW]]
[[Category: Yue, W W.]]
[[Category: Von Delft F]]
[[Category: Dehydrogenase/reductase]]
[[Category: Oxidoreductase]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
Retrieved from "https://proteopedia.org/3o4r"