3o4z: Difference between revisions

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{{STRUCTURE_3o4z|  PDB=3o4z  |  SCENE=  }}
===Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes===
{{ABSTRACT_PUBMED_20801936}}


==Function==
==Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes==
[[http://www.uniprot.org/uniprot/TEL2_YEAST TEL2_YEAST]] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.  
<StructureSection load='3o4z' size='340' side='right'caption='[[3o4z]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3o4z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4Z FirstGlance]. <br>
[[3o4z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4z OCA], [https://pdbe.org/3o4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4z RCSB], [https://www.ebi.ac.uk/pdbsum/3o4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4z ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:020801936</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/TEL2_YEAST TEL2_YEAST] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/3o4z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o4z ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Pavletich, N P.]]
[[Category: Pavletich NP]]
[[Category: Xie, Y.]]
[[Category: Xie Y]]
[[Category: Heat like helical repeat]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/3o4z"