3o8h: Difference between revisions
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== | ==EthR from Mycobacterium tuberculosis in complex with compound BDM14950== | ||
[[http://www.uniprot.org/uniprot/ | <StructureSection load='3o8h' size='340' side='right'caption='[[3o8h]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3o8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O8H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O8H:4-IODO-N-[(1-{2-OXO-2-[4-(3-THIOPHEN-2-YL-1,2,4-OXADIAZOL-5-YL)PIPERIDIN-1-YL]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL]BENZENESULFONAMIDE'>O8H</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o8h OCA], [https://pdbe.org/3o8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o8h RCSB], [https://www.ebi.ac.uk/pdbsum/3o8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o8h ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/3o8h_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o8h ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
[[ | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Baulard | [[Category: Baulard A]] | ||
[[Category: Deprez | [[Category: Deprez B]] | ||
[[Category: Desroses | [[Category: Desroses M]] | ||
[[Category: Diri | [[Category: Diri B]] | ||
[[Category: Lens | [[Category: Lens Z]] | ||
[[Category: Locht | [[Category: Locht C]] | ||
[[Category: Rucktooa | [[Category: Rucktooa P]] | ||
[[Category: Toto | [[Category: Toto P]] | ||
[[Category: Villeret | [[Category: Villeret V]] | ||
[[Category: Willand | [[Category: Willand N]] | ||
Latest revision as of 10:33, 21 February 2024
EthR from Mycobacterium tuberculosis in complex with compound BDM14950
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