3o3i: Difference between revisions

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{{STRUCTURE_3o3i|  PDB=3o3i  |  SCENE=  }}
===Crystal Structure of human Hiwi1 PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OH at its 3'-end===
{{ABSTRACT_PUBMED_21193640}}


==Function==
==Crystal Structure of human Hiwi1 PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OH at its 3'-end==
[[http://www.uniprot.org/uniprot/PIWL1_HUMAN PIWL1_HUMAN]] Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.<ref>PMID:12037681</ref> <ref>PMID:14749716</ref> <ref>PMID:16287078</ref>
<StructureSection load='3o3i' size='340' side='right'caption='[[3o3i]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3o3i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O3I FirstGlance]. <br>
[[3o3i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3I OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o3i OCA], [https://pdbe.org/3o3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o3i RCSB], [https://www.ebi.ac.uk/pdbsum/3o3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o3i ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:021193640</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/PIWL1_HUMAN PIWL1_HUMAN] Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.<ref>PMID:12037681</ref> <ref>PMID:14749716</ref> <ref>PMID:16287078</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ma, J B.]]
[[Category: Large Structures]]
[[Category: Patel, D J.]]
[[Category: Ma J-B]]
[[Category: Simanshu, D K.]]
[[Category: Patel DJ]]
[[Category: Tian, Y.]]
[[Category: Simanshu DK]]
[[Category: Hili]]
[[Category: Tian Y]]
[[Category: Hiwi1]]
[[Category: Paz]]
[[Category: Paz domain]]
[[Category: Pi-rna]]
[[Category: Piwi]]
[[Category: Rna binding protein]]
[[Category: Rna silencing]]
Retrieved from "https://proteopedia.org/3o3i"