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{{STRUCTURE_3nkz|  PDB=3nkz  |  SCENE=  }}
===The crystal structure of a flagella protein from Yersinia enterocolitica subsp. enterocolitica 8081===


==Function==
==The crystal structure of a flagella protein from Yersinia enterocolitica subsp. enterocolitica 8081==
[[http://www.uniprot.org/uniprot/FLIT_YERE8 FLIT_YERE8]] Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity).  
<StructureSection load='3nkz' size='340' side='right'caption='[[3nkz]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nkz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica_subsp._enterocolitica_8081 Yersinia enterocolitica subsp. enterocolitica 8081]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NKZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.112&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nkz OCA], [https://pdbe.org/3nkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nkz RCSB], [https://www.ebi.ac.uk/pdbsum/3nkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nkz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FLIT_YERE8 FLIT_YERE8] Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/3nkz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nkz ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[3nkz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica_subsp._enterocolitica Yersinia enterocolitica subsp. enterocolitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKZ OCA].
*[[Flagellar protein 3D structures|Flagellar protein 3D structures]]
[[Category: Yersinia enterocolitica subsp. enterocolitica]]
__TOC__
[[Category: Feldmann, B.]]
</StructureSection>
[[Category: Joachimiak, A.]]
[[Category: Large Structures]]
[[Category: Li, H.]]
[[Category: Yersinia enterocolitica subsp. enterocolitica 8081]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Feldmann B]]
[[Category: Tan, K.]]
[[Category: Joachimiak A]]
[[Category: Mcsg]]
[[Category: Li H]]
[[Category: Midwest center for structural genomic]]
[[Category: Tan K]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/3nkz"