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{{STRUCTURE_3ne0|  PDB=3ne0  |  SCENE=  }}
===Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation===
{{ABSTRACT_PUBMED_20826344}}


==Function==
==Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation==
[[http://www.uniprot.org/uniprot/O53168_MYCTU O53168_MYCTU]] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref>
<StructureSection load='3ne0' size='340' side='right'caption='[[3ne0]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3ne0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NE0 FirstGlance]. <br>
[[3ne0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NE0 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ne0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ne0 OCA], [https://pdbe.org/3ne0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ne0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ne0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ne0 ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:020826344</ref><references group="xtra"/><references/>
== Function ==
[[Category: Mycobacterium tuberculosis]]
[https://www.uniprot.org/uniprot/RIPA_MYCTU RIPA_MYCTU] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref>  
[[Category: Berisio, R.]]
== Evolutionary Conservation ==
[[Category: Ruggiero, A.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Squeglia, F.]]
Check<jmol>
[[Category: Cell wall]]
  <jmolCheckbox>
[[Category: Hydrolase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/3ne0_consurf.spt"</scriptWhenChecked>
[[Category: Peptidoglycan]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Tuberculosis]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ne0 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Berisio R]]
[[Category: Ruggiero A]]
[[Category: Squeglia F]]
Retrieved from "https://proteopedia.org/3ne0"