Shikimate kinase: Difference between revisions

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[[Image:2dfn.png|left|200px|thumb|Crystal structure of shikimate kinase complex with shikimate and ADP [[2dfn]]]]
<StructureSection load='2dfn' size='350' side='right' scene='54/543316/Cv/2' caption='Shikimate kinase complex with shikimate and ADP [[2dfn]]'>
{{STRUCTURE_2dfn|  PDB=2dfn  | SIZE=350| SCENE= |right|CAPTION=Shikimate kinase complex with shikimate and ADP [[2dfn]] }}
__TOC__
== Function ==
'''Shikimate kinase'''  (SK) catalyzes the ATP-dependent phosphorylation of shikimate to produce shikimate 3-phosphate.  It is part of the plant and bacteria pathway of synthesizing aromatic acids<ref>PMID:21366533</ref>.  


== Relevance ==
SK inhibitors can be used as antimicrobial drugs<ref>PMID:25861218</ref>.


 
== Structural highlights ==
 
The active site of SK contains the substrate shikimate and an ADP molecule<ref>PMID:17183161</ref>.
 
*<scene name='54/543316/Cv/12'>ADP binding site</scene>. Water molecules are shown as red spheres.
 
*<scene name='54/543316/Cv/13'>Whole binding site</scene>.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
'''Shikimate kinase'''  (SK) catalyzes the ATP-dependent phosphorylation of shikimate to produce shikimate 3-phosphate. It is part of the plant and bacteria pathway of synthesizing aromatic acids. SK inhibitors can be used as antimicrobial drugs.


== 3D Structures of shikimate kinase ==
== 3D Structures of shikimate kinase ==
[[Shikimate kinase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== References ==
 
</StructureSection>
[[2g1j]], [[2iyt]] – MtSK – ''Mycobacterium tuberculosis''<br />
<references/>
[[2pt5]] – SK – ''Aquifex aeolicus'' <br />
[[Category: Topic Page]]
[[3nwj]] – SK – ''Arabidopsis thaliana''<br />
[[3trf]] – SK – ''Coxiella burnetii''<br />
[[3vaa]] – SK – ''Bacterioides thetaiotaomicron''<br />
[[1via]] – SK – ''Campylobacter jejuni''<br />
[[1zuh]], [[3hr7]] – HpSK – ''Helicobacter pylori''<br />
[[3mrs]] – HpSK (mutant)<br />
 
===Shikimate kinase  binary complex===
 
[[1l4u]], [[1l4y]], [[1u8a]], [[2iyu]], [[2iyv]], [[2dft]] – MtSK + ADP <br />
[[2iyw]] – MtSK + ATP <br />
[[3baf]] – MtSK + AMPPNP <br />
[[1zui]] – HpSK + shikimate<br />
[[3n2e]] – HpSK (mutant) + inhibitor<br />
[[2g1k]], [[2iyr]], [[2iys]], [[2iyx]] – MtSK + shikimate<br />
[[2iyy]] – MtSK + shikimate-3-phosphate<br />
 
===Shikimate kinase  ternary complex===
 
[[2iyz]] – MtSK + ADP + shikimate-3-phosphate<br />
[[1we2]], [[2dfn]], [[2iyq]] – MtSK + ADP + shikimate<br />
[[1zyu]] – MtSK + AMPPCP + shikimate<br />
[[3muf]] – HpSK + ADP + shikimate-3-phosphate<br />

Latest revision as of 07:55, 21 March 2022

Shikimate kinase complex with shikimate and ADP 2dfn

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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