3qej: Difference between revisions
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== | ==S74E-dCK mutant in complex with UDP== | ||
[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN | <StructureSection load='3qej' size='340' side='right'caption='[[3qej]], [[Resolution|resolution]] 2.49Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3qej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QEJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qej OCA], [https://pdbe.org/3qej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qej RCSB], [https://www.ebi.ac.uk/pdbsum/3qej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qej ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref> | |||
==See Also== | ==See Also== | ||
*[[Deoxycytidine kinase|Deoxycytidine kinase]] | *[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]] | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Hazra S]] | ||
[[Category: | [[Category: Lavie A]] | ||
Latest revision as of 10:47, 21 February 2024
S74E-dCK mutant in complex with UDP
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