2g86: Difference between revisions

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[[Image:2g86.gif|left|200px]]<br /><applet load="2g86" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2g86, resolution 2.40&Aring;" />
'''L. casei thymidylate synthase Y261F in complex with substrate, dUMP'''<br />


==About this Structure==
==L. casei thymidylate synthase Y261F in complex with substrate, dUMP==
2G86 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with <scene name='pdbligand=UMP:'>UMP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G86 OCA].
<StructureSection load='2g86' size='340' side='right'caption='[[2g86]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
[[Category: Lactobacillus casei]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2g86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G86 FirstGlance]. <br>
[[Category: Thymidylate synthase]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Finer-Moore, J S.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
[[Category: Stroud, R M.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g86 OCA], [https://pdbe.org/2g86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g86 RCSB], [https://www.ebi.ac.uk/pdbsum/2g86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g86 ProSAT]</span></td></tr>
[[Category: UMP]]
</table>
[[Category: dump complex]]
== Function ==
[[Category: dump-binding residue]]
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
[[Category: thymidylate synthase mutant]]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g86_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g86 ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:05 2008''
==See Also==
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Lacticaseibacillus casei]]
[[Category: Large Structures]]
[[Category: Finer-Moore JS]]
[[Category: Stroud RM]]
Retrieved from "https://proteopedia.org/2g86"