3qeo: Difference between revisions

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{{STRUCTURE_3qeo|  PDB=3qeo  |  SCENE=  }}
===S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP===
{{ABSTRACT_PUBMED_21351740}}


==Function==
==S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP==
[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
<StructureSection load='3qeo' size='340' side='right'caption='[[3qeo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3qeo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QEO FirstGlance]. <br>
[[3qeo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEO OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.897&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLT:L-DEOXYTHYMIDINE'>LLT</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qeo OCA], [https://pdbe.org/3qeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qeo RCSB], [https://www.ebi.ac.uk/pdbsum/3qeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qeo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>  


==See Also==
==See Also==
*[[Deoxycytidine kinase|Deoxycytidine kinase]]
*[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021351740</ref><references group="xtra"/><references/>
__TOC__
[[Category: Deoxycytidine kinase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hazra, S.]]
[[Category: Large Structures]]
[[Category: Lavie, A.]]
[[Category: Hazra S]]
[[Category: Alpha/beta]]
[[Category: Lavie A]]
[[Category: Phosphoryl transfer]]
[[Category: Transferase]]
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