3phn: Difference between revisions

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{{STRUCTURE_3phn|  PDB=3phn  |  SCENE=  }}
===Crystal structure of wild-type onconase with resolution 1.46 A===


==Function==
==Crystal structure of wild-type onconase with resolution 1.46 A==
[[http://www.uniprot.org/uniprot/RNP30_RANPI RNP30_RANPI]] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.  
<StructureSection load='3phn' size='340' side='right'caption='[[3phn]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3phn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_pipiens Lithobates pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHN FirstGlance]. <br>
[[3phn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_pipiens Rana pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHN OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
[[Category: Rana pipiens]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Kurpiewska, K.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phn OCA], [https://pdbe.org/3phn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phn RCSB], [https://www.ebi.ac.uk/pdbsum/3phn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phn ProSAT]</span></td></tr>
[[Category: Lewinski, K.]]
</table>
[[Category: Loch, J.]]
== Function ==
[[Category: Ribo, M.]]
[https://www.uniprot.org/uniprot/RNP30_LITPI RNP30_LITPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
[[Category: Torrent, G.]]
__TOC__
[[Category: Vilanova, M.]]
</StructureSection>
[[Category: Alpha and beta protein]]
[[Category: Large Structures]]
[[Category: Antitumor protein]]
[[Category: Lithobates pipiens]]
[[Category: Endonuclease]]
[[Category: Kurpiewska K]]
[[Category: Hydrolase]]
[[Category: Lewinski K]]
[[Category: Nuclease]]
[[Category: Loch J]]
[[Category: Onconase]]
[[Category: Ribo M]]
[[Category: Protein p-30]]
[[Category: Torrent G]]
[[Category: Ranpirnase]]
[[Category: Vilanova M]]

Latest revision as of 09:54, 6 September 2023

Crystal structure of wild-type onconase with resolution 1.46 A

3phn, resolution 1.46Å

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