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{{STRUCTURE_3q91|  PDB=3q91  |  SCENE=  }}
===Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)===


==Function==
==Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)==
[[http://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN]] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.  
<StructureSection load='3q91' size='340' side='right'caption='[[3q91]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3q91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q91 FirstGlance]. <br>
[[3q91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q91 OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q91 OCA], [https://pdbe.org/3q91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q91 RCSB], [https://www.ebi.ac.uk/pdbsum/3q91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q91 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: UDP-sugar diphosphatase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Berg, S Van Der.]]
[[Category: Berglund H]]
[[Category: Berglund, H.]]
[[Category: Bountra C]]
[[Category: Bountra, C.]]
[[Category: Collins R]]
[[Category: Collins, R.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Ekblad T]]
[[Category: Ekblad, T.]]
[[Category: Flodin S]]
[[Category: Flodin, S.]]
[[Category: Flores A]]
[[Category: Flores, A.]]
[[Category: Graslund S]]
[[Category: Graslund, S.]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M.]]
[[Category: Johansson I]]
[[Category: Johansson, I.]]
[[Category: Karlberg T]]
[[Category: Karlberg, T.]]
[[Category: Kol S]]
[[Category: Kol, S.]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T.]]
[[Category: Kouznetsova E]]
[[Category: Kouznetsova, E.]]
[[Category: Moche M]]
[[Category: Moche, M.]]
[[Category: Nordlund P]]
[[Category: Nordlund, P.]]
[[Category: Nyman T]]
[[Category: Nyman, T.]]
[[Category: Persson C]]
[[Category: Persson, C.]]
[[Category: Schuler H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Schutz P]]
[[Category: Schuler, H.]]
[[Category: Siponen MI]]
[[Category: Schutz, P.]]
[[Category: Thorsell AG]]
[[Category: Siponen, M I.]]
[[Category: Tresaugues L]]
[[Category: Thorsell, A G.]]
[[Category: Van Der Berg S]]
[[Category: Tresaugues, L.]]
[[Category: Wahlberg E]]
[[Category: Wahlberg, E.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Welin M]]
[[Category: Welin, M.]]
[[Category: Hydrolase]]
[[Category: Magnesium binding]]
[[Category: Mutt-like]]
[[Category: Nudix]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Latest revision as of 11:37, 14 March 2024

Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)

3q91, resolution 2.70Å

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