3q2t: Difference between revisions

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{{STRUCTURE_3q2t|  PDB=3q2t  |  SCENE=  }}
===Crystal Structure of CFIm68 RRM/CFIm25/RNA complex===
{{ABSTRACT_PUBMED_21295486}}


==Function==
==Crystal Structure of CFIm68 RRM/CFIm25/RNA complex==
[[http://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN]] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref> [[http://www.uniprot.org/uniprot/CPSF6_HUMAN CPSF6_HUMAN]] Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:21295486</ref>
<StructureSection load='3q2t' size='340' side='right'caption='[[3q2t]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3q2t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2T FirstGlance]. <br>
[[3q2t]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2T OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.061&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2t OCA], [https://pdbe.org/3q2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2t RCSB], [https://www.ebi.ac.uk/pdbsum/3q2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2t ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:021295486</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/CPSF6_HUMAN CPSF6_HUMAN] Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:21295486</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Coseno, M.]]
[[Category: Large Structures]]
[[Category: Doublie, S.]]
[[Category: Coseno M]]
[[Category: Gilmartin, G M.]]
[[Category: Doublie S]]
[[Category: Yang, Q.]]
[[Category: Gilmartin GM]]
[[Category: 3' end processing]]
[[Category: Yang Q]]
[[Category: Cfim]]
[[Category: Cfim25]]
[[Category: Cfim68]]
[[Category: Cleavage factor]]
[[Category: Cpsf]]
[[Category: Cpsf5]]
[[Category: Cpsf6]]
[[Category: Nudix fold]]
[[Category: Nudix protein]]
[[Category: Protein-protein complex]]
[[Category: Protein-rna complex]]
[[Category: Rna binding protein-rna complex]]
[[Category: Rna processing]]
[[Category: Rrm]]
Retrieved from "https://proteopedia.org/3q2t"