4kne: Difference between revisions
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New page: '''Unreleased structure''' The entry 4kne is ON HOLD Authors: Dias, M.V.B, Tyrakis, P., Blundell , T.L. Description: Crystal structure of dihydrofolate reductase from Mycobacterium tub... |
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==Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil== | |||
<StructureSection load='4kne' size='340' side='right'caption='[[4kne]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4kne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KNE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kne OCA], [https://pdbe.org/4kne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kne RCSB], [https://www.ebi.ac.uk/pdbsum/4kne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kne ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==See Also== | |||
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Blundell TL]] | |||
[[Category: Dias MVB]] | |||
[[Category: Tyrakis P]] | |||
Latest revision as of 12:14, 1 March 2024
Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil
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