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{{STRUCTURE_4jjn|  PDB=4jjn  |  SCENE=  }}
===Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome===
{{ABSTRACT_PUBMED_23650358}}


==Function==
==Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome==
[[http://www.uniprot.org/uniprot/H2B2_YEAST H2B2_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[http://www.uniprot.org/uniprot/H2A2_YEAST H2A2_YEAST]] Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11140636</ref> <ref>PMID:15458641</ref> <ref>PMID:15610741</ref> <ref>PMID:16299494</ref> [[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
<StructureSection load='4jjn' size='340' side='right'caption='[[4jjn]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jjn]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.09&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjn OCA], [https://pdbe.org/4jjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jjn RCSB], [https://www.ebi.ac.uk/pdbsum/4jjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H3_YEAST H3_YEAST]  


==About this Structure==
==See Also==
[[4jjn]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJN OCA].
*[[Histone 3D structures|Histone 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Currie, M.]]
[[Category: Currie M]]
[[Category: Johnson, A.]]
[[Category: Johnson A]]
[[Category: Li, G.]]
[[Category: Li G]]
[[Category: Lu, C.]]
[[Category: Lu C]]
[[Category: Moazed, D.]]
[[Category: Moazed D]]
[[Category: Mohammed, A.]]
[[Category: Mohammed A]]
[[Category: Wang, F.]]
[[Category: Wang F]]
[[Category: Bah domain]]
[[Category: Dna binding protein-dna complex]]
[[Category: Silencing]]

Latest revision as of 12:04, 1 March 2024

Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome

4jjn, resolution 3.09Å

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