3wrp: Difference between revisions
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== | ==FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR== | ||
[[http://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI | <StructureSection load='3wrp' size='340' side='right'caption='[[3wrp]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[3wrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WRP FirstGlance]. <br> | ||
[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrp OCA], [https://pdbe.org/3wrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wrp RCSB], [https://www.ebi.ac.uk/pdbsum/3wrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrp ProSAT]</span></td></tr> | |||
</table> | |||
< | == Function == | ||
[https://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/3wrp_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3wrp ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Sigler PB]] | ||
[[Category: | [[Category: Zhang R-G]] | ||
Latest revision as of 10:35, 1 March 2024
FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
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