4bnd: Difference between revisions
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New page: '''Unreleased structure''' The entry 4bnd is ON HOLD Authors: Nogly, P., Matias, P., Rosa, M., Castro, R., Santos, H., Neves, A.R., Archer, M. Description: Structure of an atypical alp... |
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The | ==Structure of an atypical alpha-phosphoglucomutase similar to eukaryotic phosphomannomutases== | ||
<StructureSection load='4bnd' size='340' side='right'caption='[[4bnd]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4bnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._cremoris_MG1363 Lactococcus lactis subsp. cremoris MG1363]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BND FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bnd OCA], [https://pdbe.org/4bnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bnd RCSB], [https://www.ebi.ac.uk/pdbsum/4bnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bnd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A2RIP9_LACLM A2RIP9_LACLM] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The first structure of a bacterial alpha-phosphoglucomutase with an overall fold similar to eukaryotic phosphomannomutases is reported. Unlike most alpha-phosphoglucomutases within the alpha-D-phosphohexomutase superfamily, it belongs to subclass IIb of the haloacid dehalogenase superfamily (HADSF). It catalyzes the reversible conversion of alpha-glucose 1-phosphate to glucose 6-phosphate. The crystal structure of alpha-phosphoglucomutase from Lactococcus lactis (APGM) was determined at 1.5 A resolution and contains a sulfate and a glycerol bound at the enzyme active site that partially mimic the substrate. A dimeric form of APGM is present in the crystal and in solution, an arrangement that may be functionally relevant. The catalytic mechanism of APGM and its strict specificity towards alpha-glucose 1-phosphate are discussed. | |||
High-resolution structure of an atypical alpha-phosphoglucomutase related to eukaryotic phosphomannomutases.,Nogly P, Matias PM, de Rosa M, Castro R, Santos H, Neves AR, Archer M Acta Crystallogr D Biol Crystallogr. 2013 Oct 1;69(Pt 10):2008-2016. Epub 2013, Sep 20. PMID:24100319<ref>PMID:24100319</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4bnd" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lactococcus lactis subsp. cremoris MG1363]] | |||
[[Category: Large Structures]] | |||
[[Category: Archer M]] | |||
[[Category: Castro R]] | |||
[[Category: De Rosa M]] | |||
[[Category: Matias PM]] | |||
[[Category: Neves AR]] | |||
[[Category: Nogly P]] | |||
[[Category: Santos H]] | |||
Latest revision as of 11:02, 9 May 2024
Structure of an atypical alpha-phosphoglucomutase similar to eukaryotic phosphomannomutases
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