4bqm: Difference between revisions
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New page: '''Unreleased structure''' The entry 4bqm is ON HOLD Authors: Ferreira, I.M., Vollmar, M., Krojer, T., Strain-Damerell, C., Froese, S., Coutandin, D., Williams, E., Burgess-Brown, N., v... |
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==Crystal structure of human liver-type glutaminase, catalytic domain== | |||
<StructureSection load='4bqm' size='340' side='right'caption='[[4bqm]], [[Resolution|resolution]] 2.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4bqm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqm OCA], [https://pdbe.org/4bqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqm RCSB], [https://www.ebi.ac.uk/pdbsum/4bqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLSL_HUMAN GLSL_HUMAN] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.<ref>PMID:20378837</ref> | |||
==See Also== | |||
*[[Glutaminase 3D structures|Glutaminase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ambrosio ALB]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Burgess-Brown N]] | |||
[[Category: Coutandin D]] | |||
[[Category: Dias SMG]] | |||
[[Category: Edwards A]] | |||
[[Category: Ferreira IM]] | |||
[[Category: Froese S]] | |||
[[Category: Krojer T]] | |||
[[Category: Strain-Damerell C]] | |||
[[Category: Vollmar M]] | |||
[[Category: Williams E]] | |||
[[Category: Yue WW]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 11:56, 20 December 2023
Crystal structure of human liver-type glutaminase, catalytic domain
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