4l41: Difference between revisions
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New page: '''Unreleased structure''' The entry 4l41 is ON HOLD Authors: Ramakrishnan, B., Qasba, P.K. Description: Human Lactose synthase: A 2:1 complex between human alpha-lactalbumin and human... |
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==Human Lactose synthase: A 2:1 complex between human alpha-lactalbumin and human beta1,4-galactosyltransferase== | |||
<StructureSection load='4l41' size='340' side='right'caption='[[4l41]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l41]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L41 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l41 OCA], [https://pdbe.org/4l41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l41 RCSB], [https://www.ebi.ac.uk/pdbsum/4l41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l41 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LALBA_HUMAN LALBA_HUMAN] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. | |||
==See Also== | |||
*[[Alpha-lactalbumin 3D structures|Alpha-lactalbumin 3D structures]] | |||
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Qasba PK]] | |||
[[Category: Ramakrishnan B]] | |||
Latest revision as of 16:11, 20 September 2023
Human Lactose synthase: A 2:1 complex between human alpha-lactalbumin and human beta1,4-galactosyltransferase
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