4l5a: Difference between revisions
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New page: '''Unreleased structure''' The entry 4l5a is ON HOLD Authors: Torini, J.R., DeMarco, R., Brandao-Neto, J., Pereira, H.M. Description: Methylthioadenosine phosphorylase from Schistosoma... |
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==Methylthioadenosine phosphorylase from Schistosoma mansoni in complex with tubercidin== | |||
<StructureSection load='4l5a' size='340' side='right'caption='[[4l5a]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l5a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2993Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TBN:2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL'>TBN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5a OCA], [https://pdbe.org/4l5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5a RCSB], [https://www.ebi.ac.uk/pdbsum/4l5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5a ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/I0B503_SCHMA I0B503_SCHMA] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (By similarity).[HAMAP-Rule:MF_03155] | |||
==See Also== | |||
*[[5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures|5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Schistosoma mansoni]] | |||
[[Category: Brandao-Neto J]] | |||
[[Category: DeMarco R]] | |||
[[Category: Pereira HM]] | |||
[[Category: Torini JR]] | |||
