4l5f: Difference between revisions
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New page: '''Unreleased structure''' The entry 4l5f is ON HOLD Authors: Edeling, M.A., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) Description: Cry... |
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==Crystal Structure of DENV1-E106 Fab bound to DENV-1 Envelope protein DIII== | |||
<StructureSection load='4l5f' size='340' side='right'caption='[[4l5f]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l5f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5f OCA], [https://pdbe.org/4l5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5f RCSB], [https://www.ebi.ac.uk/pdbsum/4l5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5f ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q8BE40_9FLAV Q8BE40_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
*[[3D structures of non-human antibody|3D structures of non-human antibody]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dengue virus 1]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Edeling MA]] | |||
[[Category: Fremont DH]] | |||
[[Category: Nelson CA]] | |||
Latest revision as of 07:08, 27 November 2024
Crystal Structure of DENV1-E106 Fab bound to DENV-1 Envelope protein DIII
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