4l63: Difference between revisions

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'''Unreleased structure'''


The entry 4l63 is ON HOLD
==Apo form of AB5 holotoxin==
<StructureSection load='4l63' size='340' side='right'caption='[[4l63]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4l63]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L63 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l63 OCA], [https://pdbe.org/4l63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l63 RCSB], [https://www.ebi.ac.uk/pdbsum/4l63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l63 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8GAV4_ECOLX Q8GAV4_ECOLX]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
AB5 toxins are composed of an enzymatic A subunit that disrupts cellular function associated with a pentameric B subunit required for host cell invasion. EcxAB is an AB5 toxin isolated from clinical strains of Escherichia coli classified as part of the cholera family due to B subunit homology. Cholera-group toxins have catalytic ADP-ribosyltransferases as their A subunits, so it was surprising that EcxA did not. We confirmed that EcxAB self-associates as a functional toxin and obtained its structure. EcxAB is a prototypical member of a hybrid AB5 toxin family containing metzincin-type metalloproteases as their active A subunit paired to a cholera-like B subunit. Furthermore, EcxA is distinct from previously characterized proteases and thus founds an AB5-associated metzincin family that we term the toxilysins. EcxAB provides the first observation of conserved B subunit usage across different AB5 toxin families and provides evidence that the intersubunit interface of these toxins is far more permissive than previously supposed.


Authors: Littler, D. R., Ng, N. M., Rossjohn J., Beddoe T.
EcxAB Is a Founding Member of a New Family of Metalloprotease AB Toxins with a Hybrid Cholera-like B Subunit.,Ng NM, Littler DR, Paton AW, Le Nours J, Rossjohn J, Paton JC, Beddoe T Structure. 2013 Oct 1. pii: S0969-2126(13)00345-6. doi:, 10.1016/j.str.2013.08.024. PMID:24095060<ref>PMID:24095060</ref>


Description: Apo form of AB5 holotoxin
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4l63" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Beddoe T]]
[[Category: Littler DR]]
[[Category: Ng NM]]
[[Category: Rossjohn J]]
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