4l6c: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
New page: '''Unreleased structure''' The entry 4l6c is ON HOLD Authors: Pachl, P., Brynda, J., Rezacova, P. Description: CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL DEOXYRIBONUCLEOTIDASE IN COMPLEX...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 4l6c is ON HOLD
==Crystal structure of human mitochondrial deoxyribonucleotidase in complex with the inhibitor pib-t==
 
<StructureSection load='4l6c' size='340' side='right'caption='[[4l6c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
Authors: Pachl, P., Brynda, J., Rezacova, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4l6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L6C FirstGlance]. <br>
Description: CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL DEOXYRIBONUCLEOTIDASE IN COMPLEX WITH THE INHIBITOR PIB-T
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0BT:1-{2-DEOXY-3,5-O-[(4-IODOPHENYL)(PHOSPHONO)METHYLIDENE]-BETA-D-THREO-PENTOFURANOSYL}-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>0BT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6c OCA], [https://pdbe.org/4l6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l6c RCSB], [https://www.ebi.ac.uk/pdbsum/4l6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l6c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brynda J]]
[[Category: Pachl P]]
[[Category: Rezacova P]]
Retrieved from "https://proteopedia.org/4l6c"