4l6s: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4l6s is ~~ON HOLD~~

==PARP complexed with benzo[1,4]oxazin-3-one inhibitor==

== Structural highlights ==

<table><tr><td colspan='2'>[[4l6s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6S OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4L6S FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WQ:(2S)-6-{[4-(4-CHLOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]METHYL}-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE'>1WQ</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4l6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6s OCA], [https://pdbe.org/4l6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l6s RCSB], [https://www.ebi.ac.uk/pdbsum/4l6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l6s ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>

~~Authors~~: Dougan~~, D.R., Mol C.D.,~~ Lawson ~~J.D.~~

==See Also==

*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]

~~Description~~: ~~PARP complexed with benzo[1,4~~]~~oxazin-3-one inhibitor.~~

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Dougan DR]]

[[Category: Lawson JD]]

[[Category: Mol CD]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4l6s is ON HOLD
+==PARP complexed with benzo[1,4]oxazin-3-one inhibitor==
+<StructureSection load='4l6s' size='340' side='right'caption='[[4l6s]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4l6s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L6S FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WQ:(2S)-6-{[4-(4-CHLOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]METHYL}-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE'>1WQ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6s OCA], [https://pdbe.org/4l6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l6s RCSB], [https://www.ebi.ac.uk/pdbsum/4l6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l6s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
-Authors: Dougan, D.R., Mol C.D., Lawson J.D.
+==See Also==
+*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
-Description: PARP complexed with benzo[1,4]oxazin-3-one inhibitor.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Dougan DR]]
+[[Category: Lawson JD]]
+[[Category: Mol CD]]