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{{STRUCTURE_4km5|  PDB=4km5  |  SCENE=  }}
===X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)===
{{ABSTRACT_PUBMED_23707061}}


==Function==
==X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)==
[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
<StructureSection load='4km5' size='340' side='right'caption='[[4km5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4km5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KM5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.499&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4km5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4km5 OCA], [https://pdbe.org/4km5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4km5 RCSB], [https://www.ebi.ac.uk/pdbsum/4km5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4km5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>  


==About this Structure==
==See Also==
[[4km5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM5 OCA].
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023707061</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Berger, J M.]]
[[Category: Large Structures]]
[[Category: Doudna, J A.]]
[[Category: Berger JM]]
[[Category: Kranzusch, P J.]]
[[Category: Doudna JA]]
[[Category: Lee, A S.Y.]]
[[Category: Kranzusch PJ]]
[[Category: Cytoplasmic]]
[[Category: Lee ASY]]
[[Category: Dna]]
[[Category: Dna sensor]]
[[Category: Innate immunity]]
[[Category: Nucleotidyl transferase]]
[[Category: Transferase]]
[[Category: Zinc finger]]
Retrieved from "https://proteopedia.org/4km5"