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{{Large structure}}
{{STRUCTURE_4k3n|  PDB=4k3n  |  SCENE=  }}
===Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum===
{{ABSTRACT_PUBMED_23713488}}


==About this Structure==
==Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum==
[[4k3n]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA].  
<StructureSection load='4k3n' size='340' side='right'caption='[[4k3n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4k3n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K3N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1OT:{(R)-AMINO[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}PHOSPHONIC+ACID'>1OT</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3n OCA], [https://pdbe.org/4k3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k3n RCSB], [https://www.ebi.ac.uk/pdbsum/4k3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k3n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8IL11_PLAF7 Q8IL11_PLAF7]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The malaria parasite &lt;i&gt;Plasmodium falciparum&lt;/i&gt; employs two metallo-aminopeptidases, P&lt;i&gt;f&lt;/i&gt;A-M1 and P&lt;I&gt;f&lt;/i&gt;A-M17, which are essential for parasite survival. Compounds that inhibit the activity of either enzyme represent leads for the development of new anti-malarial drugs. Here we report the synthesis and structure-activity-relationships of a small library of phosphonic acid arginine mimetics that probe the S1 pocket of both enzymes, and map the necessary interactions that would be important for a dual inhibitor.


==Reference==
Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from &lt;i&gt;Plasmodium falciparum&lt;/i&gt;,Kannan Sivaraman K, Paiardini A, Sienczyk M, Ruggeri C, Oellig CA, Dalton JP, Scammells PJ, Drag M, McGowan S J Med Chem. 2013 May 28. PMID:23713488<ref>PMID:23713488</ref>
<ref group="xtra">PMID:023713488</ref><references group="xtra"/><references/>
 
[[Category: Plasmodium falciparum 3d7]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: McGowan, S.]]
</div>
[[Category: Aminopeptidase]]
<div class="pdbe-citations 4k3n" style="background-color:#fffaf0;"></div>
[[Category: Hydrolase-hydrolase inhibitor complex]]
 
[[Category: Leucyl aminopeptidase]]
==See Also==
[[Category: Protease]]
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: McGowan S]]
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