2m6n: Difference between revisions

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{{STRUCTURE_2m6n|  PDB=2m6n  |  SCENE=  }}
===3D solution structure of EMI1 (Early Mitotic Inhibitor 1)===
{{ABSTRACT_PUBMED_23708605}}


==Function==
==3D solution structure of EMI1 (Early Mitotic Inhibitor 1)==
[[http://www.uniprot.org/uniprot/FBX5_HUMAN FBX5_HUMAN]] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.<ref>PMID:11988738</ref> <ref>PMID:16921029</ref>
<StructureSection load='2m6n' size='340' side='right'caption='[[2m6n]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2m6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M6N FirstGlance]. <br>
[[2m6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6N OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m6n OCA], [https://pdbe.org/2m6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m6n RCSB], [https://www.ebi.ac.uk/pdbsum/2m6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m6n ProSAT]</span></td></tr>
<ref group="xtra">PMID:023708605</ref><references group="xtra"/><references/>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FBX5_HUMAN FBX5_HUMAN] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.<ref>PMID:11988738</ref> <ref>PMID:16921029</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Brown, N G.]]
[[Category: Large Structures]]
[[Category: Frye, J J.]]
[[Category: Brown NG]]
[[Category: Jarvis, M.]]
[[Category: Frye JJ]]
[[Category: Kriwacki, R W.]]
[[Category: Jarvis M]]
[[Category: Nourse, A.]]
[[Category: Kriwacki RW]]
[[Category: Peters, J.]]
[[Category: Nourse A]]
[[Category: Petzold, G.]]
[[Category: Peters J]]
[[Category: Royappa, G R.]]
[[Category: Petzold G]]
[[Category: Schulman, B A.]]
[[Category: Royappa GR]]
[[Category: Stark, H.]]
[[Category: Schulman BA]]
[[Category: Watson, E R.]]
[[Category: Stark H]]
[[Category: Apc]]
[[Category: Watson ER]]
[[Category: Cell cycle]]
[[Category: E3 ligase]]
[[Category: Emi1]]
[[Category: Zbr]]
Retrieved from "https://proteopedia.org/2m6n"