4g2j: Difference between revisions

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{{STRUCTURE_4g2j|  PDB=4g2j  |  SCENE=  }}
===Human pde9 in complex with selective compound===
{{ABSTRACT_PUBMED_23025719}}


==Function==
==Human pde9 in complex with selective compound==
[[http://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN]] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
<StructureSection load='4g2j' size='340' side='right'caption='[[4g2j]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4g2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WF:1-CYCLOPENTYL-6-[(1R)-1-(3-PHENOXYAZETIDIN-1-YL)ETHYL]-1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE'>0WF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2j OCA], [https://pdbe.org/4g2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2j RCSB], [https://www.ebi.ac.uk/pdbsum/4g2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>  


==About this Structure==
==See Also==
[[4g2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2J OCA].
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023025719</ref><references group="xtra"/><references/>
__TOC__
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Liu, S.]]
[[Category: Large Structures]]
[[Category: Cgmp->gmp]]
[[Category: Liu S]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor]]
[[Category: Phosphodiesterase]]
Retrieved from "https://proteopedia.org/4g2j"