3tz0: Difference between revisions

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{{STRUCTURE_3tz0|  PDB=3tz0  |  SCENE=  }}
===Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex===


==Function==
==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex==
[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
<StructureSection load='3tz0' size='340' side='right'caption='[[3tz0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3tz0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZ0 FirstGlance]. <br>
[[3tz0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZ0 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03H:(2S)-2-CHLORO-4-METHYLPENTANOIC+ACID'>03H</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tz0 OCA], [https://pdbe.org/3tz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tz0 RCSB], [https://www.ebi.ac.uk/pdbsum/3tz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tz0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Chuang, D T.]]
[[Category: Chuang DT]]
[[Category: Chuang, J L.]]
[[Category: Chuang JL]]
[[Category: Gui, W J.]]
[[Category: Gui WJ]]
[[Category: Li, J.]]
[[Category: Li J]]
[[Category: Tso, S C.]]
[[Category: Tso SC]]
[[Category: Wynn, R M.]]
[[Category: Wynn RM]]
[[Category: Allosteric kinase inhibitor]]
[[Category: Bergerat nucleotide-binding fold]]
[[Category: Branched-chain alpha-ketoacid]]
[[Category: Branched-chain amino acid]]
[[Category: Diabetes and obesity]]
[[Category: Ghkl protein kinase]]
[[Category: Maple syrup urine disease]]
[[Category: Protein kinase]]
[[Category: Transferase-transferase inhibitor complex]]

Latest revision as of 10:15, 1 March 2024

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex

3tz0, resolution 2.50Å

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