4hf1: Difference between revisions

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{{STRUCTURE_4hf1|  PDB=4hf1  |  SCENE=  }}
===Crystal Structure of IscR bound to its promoter===
{{ABSTRACT_PUBMED_23644595}}


==Function==
==Crystal Structure of IscR bound to its promoter==
[[http://www.uniprot.org/uniprot/ISCR_ECOLI ISCR_ECOLI]] Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA.<ref>PMID:11742080</ref> <ref>PMID:16824106</ref> <ref>PMID:20421606</ref>
<StructureSection load='4hf1' size='340' side='right'caption='[[4hf1]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4hf1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HF1 FirstGlance]. <br>
[[4hf1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HF1 OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.222&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hf1 OCA], [https://pdbe.org/4hf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hf1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hf1 ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:023644595</ref><references group="xtra"/><references/>
== Function ==
[[Category: Escherichia coli k-12]]
[https://www.uniprot.org/uniprot/ISCR_ECOLI ISCR_ECOLI] Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA.<ref>PMID:11742080</ref> <ref>PMID:16824106</ref> <ref>PMID:20421606</ref>  
[[Category: Phillips, K J.]]
== References ==
[[Category: Rajagopalan, S R.]]
<references/>
[[Category: Dna binding]]
__TOC__
[[Category: Iron-sulfur cluster]]
</StructureSection>
[[Category: Protein-dna complex]]
[[Category: Escherichia coli]]
[[Category: Redox sensor]]
[[Category: Escherichia coli K-12]]
[[Category: Transcription-dna complex]]
[[Category: Large Structures]]
[[Category: Transcriptional regulator]]
[[Category: Phillips KJ]]
[[Category: Whth]]
[[Category: Rajagopalan SR]]
[[Category: Winged helix-turn-helix]]
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