4gh8: Difference between revisions

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{{STRUCTURE_4gh8|  PDB=4gh8  |  SCENE=  }}
===Crystal structure of a 'humanized' E. coli dihydrofolate reductase===


==Function==
==Crystal structure of a 'humanized' E. coli dihydrofolate reductase==
[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.  
<StructureSection load='4gh8' size='340' side='right'caption='[[4gh8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gh8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GH8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gh8 OCA], [https://pdbe.org/4gh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gh8 RCSB], [https://www.ebi.ac.uk/pdbsum/4gh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gh8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


==About this Structure==
==See Also==
[[4gh8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GH8 OCA].
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
[[Category: Dihydrofolate reductase]]
__TOC__
[[Category: Escherichia coli k-12]]
</StructureSection>
[[Category: Benkovic, S J.]]
[[Category: Escherichia coli K-12]]
[[Category: French, J B.]]
[[Category: Large Structures]]
[[Category: Hammes-Schiffer, S.]]
[[Category: Benkovic SJ]]
[[Category: Hanoian, P.]]
[[Category: French JB]]
[[Category: Liu, C T.]]
[[Category: Hammes-Schiffer S]]
[[Category: Pringle, T H.]]
[[Category: Hanoian P]]
[[Category: Dihydrofolate reductase]]
[[Category: Liu CT]]
[[Category: Enzyme catalysis]]
[[Category: Pringle TH]]
[[Category: Evolution]]
[[Category: Oxidoreductase]]
[[Category: Tetrahydrofolate]]
Retrieved from "https://proteopedia.org/4gh8"