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{{STRUCTURE_4gql|  PDB=4gql  |  SCENE=  }}
===Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1===
{{ABSTRACT_PUBMED_23343195}}


==Function==
==Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1==
[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.  
<StructureSection load='4gql' size='340' side='right'caption='[[4gql]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE'>R47</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gql OCA], [https://pdbe.org/4gql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gql RCSB], [https://www.ebi.ac.uk/pdbsum/4gql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gql ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.


==About this Structure==
==See Also==
[[4gql]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQL OCA].
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:023343195</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Macrophage elastase]]
[[Category: Large Structures]]
[[Category: Beau, F.]]
[[Category: Beau F]]
[[Category: Cassar-Lajeunesse, E.]]
[[Category: Cassar-Lajeunesse E]]
[[Category: Devel, L.]]
[[Category: Devel L]]
[[Category: Dive, V.]]
[[Category: Dive V]]
[[Category: Stura, E A.]]
[[Category: Stura EA]]
[[Category: Vera, L.]]
[[Category: Vera L]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Metzincin]]
[[Category: Potent selective phosphinic inhibitor]]
[[Category: Zinc protease]]
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