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{{STRUCTURE_4bsr|  PDB=4bsr  |  SCENE=  }}
===Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form===


==Disease==
==Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form==
[[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma. Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:[http://omim.org/entry/610644 610644]]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Note=The disease is caused by mutations affecting the gene represented in this entry.
<StructureSection load='4bsr' size='340' side='right'caption='[[4bsr]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4bsr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BSR FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/LGR5_HUMAN LGR5_HUMAN]] Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling. [[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.<ref>PMID:16109882</ref> <ref>PMID:22575959</ref>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bsr OCA], [https://pdbe.org/4bsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bsr RCSB], [https://www.ebi.ac.uk/pdbsum/4bsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bsr ProSAT]</span></td></tr>
==About this Structure==
</table>
[[4bsr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSR OCA].  
== Function ==
 
[[https://www.uniprot.org/uniprot/LGR5_HUMAN LGR5_HUMAN]] Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling.
==Reference==
__TOC__
<references group="xtra"/><references/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Clevers, H.]]
[[Category: Large Structures]]
[[Category: Forneris, F.]]
[[Category: Clevers H]]
[[Category: Granneman, J C.M.]]
[[Category: Forneris F]]
[[Category: Gros, P.]]
[[Category: Granneman JCM]]
[[Category: Huch, M.]]
[[Category: Gros P]]
[[Category: Lau, W de.]]
[[Category: Huch M]]
[[Category: Peng, W C.]]
[[Category: Peng WC]]
[[Category: Adult stem cell]]
[[Category: De Lau W]]
[[Category: Congenital anonychia]]
[[Category: Furin domain]]
[[Category: Leucine-rich repeat]]
[[Category: Leucine-rich repeat g-protein coupled receptor]]
[[Category: Signaling protein]]
[[Category: Wnt signaling]]

Latest revision as of 17:05, 7 September 2022

Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form

4bsr, resolution 3.20Å

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