2qsh: Difference between revisions

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{{STRUCTURE_2qsh|  PDB=2qsh  |  SCENE=  }}
===Crystal structure of Rad4-Rad23 bound to a mismatch DNA===
{{ABSTRACT_PUBMED_17882165}}


==Function==
==Crystal structure of Rad4-Rad23 bound to a mismatch DNA==
[[http://www.uniprot.org/uniprot/RAD23_YEAST RAD23_YEAST]] Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. [[http://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST]] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.  
<StructureSection load='2qsh' size='340' side='right'caption='[[2qsh]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2qsh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QSH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.805&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qsh OCA], [https://pdbe.org/2qsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qsh RCSB], [https://www.ebi.ac.uk/pdbsum/2qsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qsh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qs/2qsh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qsh ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[2qsh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSH OCA].
*[[DNA repair protein Rad4|DNA repair protein Rad4]]
 
*[[UV excision repair protein|UV excision repair protein]]
==Reference==
__TOC__
<ref group="xtra">PMID:017882165</ref><references group="xtra"/><references/>
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Min, J H.]]
[[Category: Min J-H]]
[[Category: Pavletich, N P.]]
[[Category: Pavletich NP]]
[[Category: Alpha-beta structure]]
[[Category: Beta hairpin]]
[[Category: Dna binding]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna repair]]
[[Category: Dna-damage recognition]]
[[Category: Mismatch dna]]
[[Category: Nucleotide excision repair]]
[[Category: Protein-dna complex]]
[[Category: Transglutaminase fold]]
[[Category: Xeroderma pigmentosum]]
Retrieved from "https://proteopedia.org/2qsh"