2hux: Difference between revisions

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[[Image:2hux.jpg|left|200px]]<br /><applet load="2hux" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2hux, resolution 2.40&Aring;" />
'''Crystal structure of PH0725 from Pyrococcus horikoshii OT3'''<br />


==About this Structure==
==Crystal structure of PH0725 from Pyrococcus horikoshii OT3==
2HUX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii] with <scene name='pdbligand=PT:'>PT</scene> and <scene name='pdbligand=SAH:'>SAH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Diphthine_synthase Diphthine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.98 2.1.1.98] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUX OCA].
<StructureSection load='2hux' size='340' side='right'caption='[[2hux]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
[[Category: Diphthine synthase]]
== Structural highlights ==
[[Category: Pyrococcus horikoshii]]
<table><tr><td colspan='2'>[[2hux]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUX FirstGlance]. <br>
[[Category: Single protein]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Kunishima, N.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hux OCA], [https://pdbe.org/2hux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hux RCSB], [https://www.ebi.ac.uk/pdbsum/2hux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hux ProSAT], [https://www.topsan.org/Proteins/RSGI/2hux TOPSAN]</span></td></tr>
[[Category: Sugahara, M.]]
</table>
[[Category: PT]]
== Function ==
[[Category: SAH]]
[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>
[[Category: national project on protein structural and functional analyses]]
== Evolutionary Conservation ==
[[Category: nppsfa]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: pyrococcus horikoshii ot3]]
Check<jmol>
[[Category: riken structural genomics/proteomics initiative]]
  <jmolCheckbox>
[[Category: rsgi]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/2hux_consurf.spt"</scriptWhenChecked>
[[Category: structural genomics]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:46:11 2008''
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hux ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: Kunishima N]]
[[Category: Sugahara M]]
Retrieved from "https://proteopedia.org/2hux"