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{{STRUCTURE_4jbm|  PDB=4jbm  |  SCENE=  }}
===Structure of murine DNA binding protein bound with ds DNA===


==Function==
==Structure of murine DNA binding protein bound with ds DNA==
[[http://www.uniprot.org/uniprot/AIM2_MOUSE AIM2_MOUSE]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.<ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:19131592</ref> <ref>PMID:20417169</ref> <ref>PMID:20351693</ref> <ref>PMID:20351692</ref> <ref>PMID:20457908</ref> <ref>PMID:22555457</ref> <ref>PMID:21902795</ref>
<StructureSection load='4jbm' size='340' side='right'caption='[[4jbm]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4jbm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBM FirstGlance]. <br>
[[4jbm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBM OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.218&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbm OCA], [https://pdbe.org/4jbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbm RCSB], [https://www.ebi.ac.uk/pdbsum/4jbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbm ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:023567559</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/AIM2_MOUSE AIM2_MOUSE] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.<ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:19131592</ref> <ref>PMID:20417169</ref> <ref>PMID:20351693</ref> <ref>PMID:20351692</ref> <ref>PMID:20457908</ref> <ref>PMID:22555457</ref> <ref>PMID:21902795</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Cheng, G.]]
[[Category: Cheng G]]
[[Category: Crowley, C.]]
[[Category: Crowley C]]
[[Category: Ding, W.]]
[[Category: Ding W]]
[[Category: Hung, L W.]]
[[Category: Hung L-W]]
[[Category: Liu, Z J.]]
[[Category: Liu Z-J]]
[[Category: Ni, X.]]
[[Category: Ni X]]
[[Category: Ru, H.]]
[[Category: Ru H]]
[[Category: Shaw, N.]]
[[Category: Shaw N]]
[[Category: Zhao, L.]]
[[Category: Zhao L]]
[[Category: Dna]]
[[Category: Dna binding protein-dna complex]]
[[Category: Ob fold]]
Retrieved from "https://proteopedia.org/4jbm"