Selectin: Difference between revisions

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== Function ==

'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain

'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>. Three types of selectins are found:

and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: E-selectin found in endothelial cells; L-selectin found in leukocytes; P-selectin found in platelets. Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the ~~bleed~~ vessel walls, slowing their motion and enabling them to enter the site of infection.

*'''E-selectin''' found in endothelial cells

*'''L-selectin''' found in leukocytes

*'''P-selectin''' found in platelets.

== Relevance ==

Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the blood vessel walls, slowing their motion and enabling them to enter the site of infection<ref>PMID:12829015</ref>. E-selectin levels correlate with disease activity in psoriasis patients<ref>PMID:10233646</ref>. L-selectin levels correlate with disease activity in type I diabetes<ref>PMID:10692053</ref>.

== Structural insight ==

The <scene name='55/552185/Cv/4'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/5'>Ca coordination site</scene>.

</StructureSection>

==3D structures of selectin==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

{{#tree:id=OrganizedByTopic|openlevels=0|

*P-selectin

~~'''~~P-selectin~~'''~~

**[[1fsb]] – hCD62P EGF domain – human - NMR

**[[1g1q]] – hCD62P EGF domain

**[[1g1r]] – hCD62P EGF domain + tetrasaccharide

**[[1g1s]] – hCD62P EGF domain +P-selectin glycoprotein ligand peptide

**[[4gxb]] – hCD62P intracellular domain + sorting nexin-17

~~[[1fsb]] – hCD62P EGF domain – human - NMR ~~

*L-selectin

~~[[1g1q]] – hCD62P EGF domain ~~

~~[[1g1r]] – hCD62P EGF domain + tetrasaccharide ~~

~~[[1g1s]] – hCD62P EGF domain +P~~-selectin ~~glycoprotein ligand peptide ~~

~~[[4gxb]] – hCD62P intracellular domain + sorting nexin-17 ~~

~~'''L~~-~~selectin'''~~

**[[3cfw]] – hCD62L EGF domain

**[[5vc1]] – hCD62L EGF domain (mutant)

**[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin

~~[[3cfw]] – hCD62L EGF domain ~~

*E-selectin

~~[[2lgf]] – hCD62L calmodulin~~-~~binding domain + calmodulin ~~

~~'''E~~-~~selectin'''~~

**[[1esl]] – hCD62E EGF domain

**[[1g1t]] – hCD62E EGF domain + tetrasaccharide

**[[4c16]] – hCD62 EGF+SCR domains + antagonist

**[[4csy]], [[6eyi]], [[6eyj]], [[6eyk]] - hCD62 EGF+SCR domains + ligand

~~[[1esl]] – hCD62E EGF domain~~

}}

[[~~1g1t~~]] ~~– hCD62E EGF domain + tetrasaccharide ~~

== References ==

[[Category:Topic Page]]

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-<StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (PDB entry [[1g1r]])' scene=''>
+<StructureSection load='1g1r' size='350' side='right' caption='Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry [[1g1r]])' scene='55/552185/Cv/1'>
+== Function ==
-'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins.  The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain
+'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins.  The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain<ref>PMID:7542213</ref>.  Three types of selectins are found:<br />
-and a number of concensus repeat units, a transmembranal domain and a intracellular domain.  Three types of selectins are found: E-selectin found in endothelial cells; L-selectin found in leukocytes; P-selectin found in platelets.  Selectins are involved in inflammation processes.  The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the bleed vessel walls, slowing their motion and enabling them to enter the site of infection.
+*'''E-selectin''' found in endothelial cells<br />
+*'''L-selectin''' found in leukocytes<br />
+*'''P-selectin''' found in platelets.<br />
+== Relevance ==
+Selectins are involved in inflammation processes.  The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the blood vessel walls, slowing their motion and enabling them to enter the site of infection<ref>PMID:12829015</ref>.  E-selectin levels correlate with disease activity in psoriasis patients<ref>PMID:10233646</ref>.  L-selectin levels correlate with disease activity in type I diabetes<ref>PMID:10692053</ref>.
+== Structural insight ==
+The <scene name='55/552185/Cv/4'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/5'>Ca coordination site</scene>.
+</StructureSection>
 ==3D structures of selectin==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*P-selectin
-'''P-selectin'''
+**[[1fsb]] – hCD62P EGF domain – human - NMR<br />
+**[[1g1q]] – hCD62P EGF domain <br />
+**[[1g1r]] – hCD62P EGF domain + tetrasaccharide<br />
+**[[1g1s]] – hCD62P EGF domain +P-selectin glycoprotein ligand peptide<br />
+**[[4gxb]] – hCD62P intracellular domain + sorting nexin-17<br />
-[[1fsb]] – hCD62P EGF domain – human - NMR<br />
+*L-selectin
-[[1g1q]] – hCD62P EGF domain <br />
-[[1g1r]] – hCD62P EGF domain + tetrasaccharide<br />
-[[1g1s]] – hCD62P EGF domain +P-selectin glycoprotein ligand peptide<br />
-[[4gxb]] – hCD62P intracellular domain + sorting nexin-17<br />
-'''L-selectin'''
+**[[3cfw]] – hCD62L EGF domain <br />
+**[[5vc1]] – hCD62L EGF domain (mutant)<br />
+**[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br />
-[[3cfw]] – hCD62L EGF domain <br />
+*E-selectin
-[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br />
-'''E-selectin'''
+**[[1esl]] – hCD62E EGF domain <br />
+**[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br />
+**[[4c16]] – hCD62 EGF+SCR domains + antagonist <br />
+**[[4csy]],  [[6eyi]], [[6eyj]], [[6eyk]] - hCD62 EGF+SCR domains + ligand <br />
-[[1esl]] – hCD62E EGF domain <br />
+}}
-[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br />
+== References ==
+<references/>
+[[Category:Topic Page]]