4lg7: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 4lg7 is ON HOLD Authors: Xu, C., Tempel, W., Wernimont, A. K., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Structural Genomics Consorti... |
No edit summary |
||
| (8 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure MBD4 MBD domain in complex with methylated CpG DNA== | |||
<StructureSection load='4lg7' size='340' side='right'caption='[[4lg7]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4lg7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LG7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg7 OCA], [https://pdbe.org/4lg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lg7 RCSB], [https://www.ebi.ac.uk/pdbsum/4lg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lg7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref> | |||
==See Also== | |||
*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Edwards AM]] | |||
[[Category: Min J]] | |||
[[Category: Tempel W]] | |||
[[Category: Wernimont AK]] | |||
[[Category: Xu C]] | |||
Latest revision as of 10:14, 30 October 2024
Crystal structure MBD4 MBD domain in complex with methylated CpG DNA
| ||||||||||||
