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{{STRUCTURE_4foe|  PDB=4foe  |  SCENE=  }}
===Crystal Structure of recombinant human Hexokinase type I with Mannose 6-Phosphate===


==Disease==
==Crystal Structure of recombinant human Hexokinase type I with Mannose 6-Phosphate==
[[http://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN]] Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:[http://omim.org/entry/235700 235700]]. HK deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.  
<StructureSection load='4foe' size='340' side='right'caption='[[4foe]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4foe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FOE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=M6D:6-O-PHOSPHONO-BETA-D-MANNOPYRANOSE'>M6D</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4foe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4foe OCA], [https://pdbe.org/4foe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4foe RCSB], [https://www.ebi.ac.uk/pdbsum/4foe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4foe ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN] Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:[https://omim.org/entry/235700 235700]. HK deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.
== Function ==
[https://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN]


==About this Structure==
==See Also==
[[4foe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOE OCA].
*[[Hexokinase 3D structures|Hexokinase 3D structures]]
[[Category: Hexokinase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Honzatko, R B.]]
[[Category: Large Structures]]
[[Category: Shen, L.]]
[[Category: Honzatko RB]]
[[Category: Hexokinase]]
[[Category: Shen L]]
[[Category: Mannose 6-phosphate]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4foe"