DNA damage-binding protein: Difference between revisions

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[[Image:3ei1.png|left|200px|thumb|Crystal structure of human DDB1 (grey) and DDB2 (green) complex with DNA [[3ei1]]]]
<StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'>
{{STRUCTURE_3ei1|  PDB=3ei1 | SIZE=350| SCENE= |right|CAPTION=Human DDB1 (grey) and DDB2 (green) complex with DNA, TMP and tetraethylene glycol [[3ei1]] }}
__TOC__
== Function ==


'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair.  It prevents UV damage to DNA.  <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>.


DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene> (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br /> Water molecules shown as red spheres.


== Disease ==


 
Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity.  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair.  It prevents UV damage to DNA.  DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2.


== 3D Structures of DNA damage-binding protein ==
== 3D Structures of DNA damage-binding protein ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[DNA damage-binding protein 3D structures]]
 
===DDB1===
 
[[2b5l]] – hDDB + simian virus 5 protein – human<br />
[[2b5m]] – hDDB <br />
[[2b5m]], [[2b5n]] – hDDB BPB domain<br />
[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br />
[[3e0c]] – hDDB <br />
[[3i7h]], [[3i7k]], [[3i7l]], [[3i7n]], [[3i7o]], [[3i7p]], [[3i89]], [[3i8c]], [[3i8e]] – hDDB + X protein peptide<br />
[[4a11]] – hDDB + DNA excision repair protein ERCC-8<br />
 
===DDB1+DDB2===


[[3ei1]], [[3ei2]], [[4a08]], [[4a09]], [[4a0a]], [[4a0b]], [[4e54]], [[4e5z]] – hDDB + DNA<br />
== References ==
[[3ei3]], [[3ei4]] – hDDB <br />
<references/>
[[4a0k]] – hDDB + cullin-4A + ring-box protein 1<br />
</StructureSection>
[[4a0l]] – hDDB + cullin-4A + ring-box protein 1 + DNA<br />
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 07:21, 16 April 2025

Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code 3ei1).

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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