2ma5: Difference between revisions
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==Solution NMR structure of PHD type Zinc finger domain of Lysine-specific demethylase 5B (PLU-1/JARID1B) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7375C== | |||
<StructureSection load='2ma5' size='340' side='right'caption='[[2ma5]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ma5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma5 OCA], [https://pdbe.org/2ma5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> | |||
==See Also== | |||
*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Acton TB]] | |||
[[Category: Cort JR]] | |||
[[Category: Everett JK]] | |||
[[Category: Hassan F]] | |||
[[Category: Janjua H]] | |||
[[Category: Kennedy MA]] | |||
[[Category: Kohan E]] | |||
[[Category: Lee D]] | |||
[[Category: Montelione GT]] | |||
[[Category: Ramelot TA]] | |||
[[Category: Xiao R]] | |||
[[Category: Yang Y]] | |||
Latest revision as of 06:03, 15 May 2024
Solution NMR structure of PHD type Zinc finger domain of Lysine-specific demethylase 5B (PLU-1/JARID1B) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7375C
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