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{{STRUCTURE_4gr9|  PDB=4gr9  |  SCENE=  }}
===Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation===
{{ABSTRACT_PUBMED_23131339}}


==Function==
==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation==
[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
<StructureSection load='4gr9' size='340' side='right'caption='[[4gr9]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GR9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.291&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=372:N-[(3R)-3-(CYANOMETHYL)-1-METHYL-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL]ACETAMIDE'>372</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gr9 OCA], [https://pdbe.org/4gr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gr9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gr9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>  


==About this Structure==
==See Also==
[[4gr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR9 OCA].
*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023131339</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Jensen, K C.]]
[[Category: Large Structures]]
[[Category: Lozinskaya, N A.]]
[[Category: Jensen KC]]
[[Category: Mesecar, A D.]]
[[Category: Lozinskaya NA]]
[[Category: Proskurnina, M V.]]
[[Category: Mesecar AD]]
[[Category: Sosonyuk, S E.]]
[[Category: Proskurnina MV]]
[[Category: Volkova, M S.]]
[[Category: Sosonyuk SE]]
[[Category: Zefirov, N S.]]
[[Category: Volkova MS]]
[[Category: Melatonin analog]]
[[Category: Zefirov NS]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/4gr9"