Met repressor: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
No edit summary |
||
| (11 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='1mjo' size='450' side='right' scene='53/536702/Cv/1' caption='EcMR (mutant) complex with corepressor SAM, Ca+2 ion (green) and DNA [[1mjo]]'> | |||
== Function == | |||
'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The co-repressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:8092669</ref>. For additional details see<br /> | |||
[[Taylor met repressor]]<br /> | |||
[[Joe Granger Methionine Repressor: Escherichia coli]]. | |||
== Structural highlights == | |||
<scene name='53/536702/Cv/7'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. <scene name='53/536702/Cv/8'>SAM binds to MR in a hydrophobic pocket between 2 monomers</scene><ref>PMID:10986458</ref>. Water molecules are shown as red spheres. | |||
</StructureSection> | |||
== 3D Structures of Met repressor == | == 3D Structures of Met repressor == | ||
| Line 38: | Line 20: | ||
[[1mjl]], [[1mjp]] – EcMR (mutant) + SAM<br /> | [[1mjl]], [[1mjp]] – EcMR (mutant) + SAM<br /> | ||
[[1mj2]], [[1mjo]], [[1mjq]] – EcMR (mutant) + SAM + DNA<br /> | [[1mj2]], [[1mjo]], [[1mjq]] – EcMR (mutant) + SAM + DNA<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
