Rhomboid protease: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='450' side='right' caption='Structure of rhomboid protease complex with inhibitor isocoumarin and nonyglucoside detergent molecules (PDB entry [[2xow]])' scene='55/551211/Cv/1'> | ||
== Function == | |||
'''Rhomboid protease''' ('''GlpG''') is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. | |||
*'''Rhomboid protease YqgP''' interacts with the membrane bound metlloprotease FisH and cleaves the high-affinity Mg transporter<ref>PMID:31930742</ref>. | |||
'' | == Structural highlights == | ||
The inhibitor <scene name='55/551211/Cv/5'>isocoumarin covalently binds to the GlpG catalytic residues Ser and His</scene> (in deepskyblue)<ref>PMID:20890268</ref>. <scene name='55/551211/Cv/6'>Whole active site</scene>. Water molecules shown as red spheres. | |||
</StructureSection> | |||
== 3D Structures of rhomboid protease == | == 3D Structures of rhomboid protease == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Rhomboid protease GlpG | |||
[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]] – EcGlpG core region – ''Escherichia coli '' <BR /> | **[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR /> | ||
[[2xtu]], [[3b44]], [[2xtv]] – EcGlpG core region (mutant) <BR /> | **[[2xtu]], [[3b44]], [[2xtv]], [[5f5d]] – EcGlpG core region (mutant) <BR /> | ||
[[4hdd]] – EcGlpG N terminal <BR /> | **[[4hdd]] – EcGlpG N terminal <BR /> | ||
[[2lep]] – EcGlpG N terminal - NMR <BR /> | **[[2lep]], [[2mja]] – EcGlpG N terminal - NMR <BR /> | ||
[[ | **[[3odj]] – HiGlpG - ''Haemophilus influenzae '' <BR /> | ||
[[2nr9]] – HiGlpG (mutant) + detergent <BR /> | **[[2nr9]] – HiGlpG (mutant) + detergent <BR /> | ||
**[[2gqc]] – RP N terminal – NMR – ''Pseudomonas aeruginosa''<br /> | |||
*Rhomboid protease GlpG complex with inhibitor | |||
[[ | **[[2xow]], [[3zeb]] – EcGlpG core region + isocoumarin inhibitor <BR /> | ||
[[3txt]], [[4h1d]] – EcGlpG core region + DFP inhibitor <BR /> | **[[3txt]], [[4h1d]] – EcGlpG core region + DFP inhibitor <BR /> | ||
[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR /> | **[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR /> | ||
[[3zmh]], [[3zmi]], [[ | **[[3zmh]], [[3zmi]], [[3zmj]], [[3zot]] – EcGlpG core region + β-lactam inhibitor <BR /> | ||
**[[6pj5]], [[6pj7]], [[6pj8]], [[6pj9]], [[6pja]], [[6pjp]], [[6pjq]], [[6pjr]], [[6pju]] – EcGlpG core region + peptide aldehyde inhibitor <BR /> | |||
**[[5f5j]], [[5f5k]], [[6pj4]] – EcGlpG core region (mutant) + peptide aldehyde inhibitor <BR /> | |||
**[[4qo0]], [[4qo2]], [[5f5g]], [[5f5b]], [[5mtf]], [[5mt6]], [[5mt7]], [[5mt8]], [[6vj8]], [[6jv9]], [[6vjp]], [[6xro]], [[6xrp]] – EcGlpG core region + peptide inhibitor <BR /> | |||
**[[4qnz]] – EcGlpG core region (mutant) + peptide inhibitor <BR /> | |||
*Rhomboid protease YqgP | |||
**[[6r0j]] – YqpG – ''Bacillus subtilis'' - NMR <BR /> | |||
*Rhomboid protease GluP | |||
**[[7tj4]] – GluP + LytH – ''Staphylococcus aureus'' <BR /> | |||
}} | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
