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[[Image:2il9.gif|left|200px]]<br /><applet load="2il9" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2il9, resolution 3.100&Aring;" />
'''Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms'''<br />


==Overview==
==Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms==
Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome using a single structured RNA. Here we present the crystal structures of the ribosome-binding domain from a Dicistroviridae intergenic region IRES at 3.1 angstrom resolution, providing a view of the prefolded architecture of an all-RNA translation initiation apparatus. Docking of the structure into cryo-electron microscopy reconstructions of an IRES-ribosome complex suggests a model for ribosome manipulation by a dynamic IRES RNA.
<StructureSection load='2il9' size='340' side='right'caption='[[2il9]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2il9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plautia_stali_intestine_virus Plautia stali intestine virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IL9 FirstGlance]. <br>
2IL9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2il9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il9 OCA], [https://pdbe.org/2il9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2il9 RCSB], [https://www.ebi.ac.uk/pdbsum/2il9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2il9 ProSAT]</span></td></tr>
==Reference==
</table>
Structural basis for ribosome recruitment and manipulation by a viral IRES RNA., Pfingsten JS, Costantino DA, Kieft JS, Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17124290 17124290]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Costantino, D A.]]
[[Category: Large Structures]]
[[Category: Kieft, J S.]]
[[Category: Plautia stali intestine virus]]
[[Category: Pfingsten, J S.]]
[[Category: Costantino DA]]
[[Category: rna; ires; ribosomal binding domain; psiv; under wound helix; double-nested pseudoknot]]
[[Category: Kieft JS]]
 
[[Category: Pfingsten JS]]
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