4lku: Difference between revisions
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New page: '''Unreleased structure''' The entry 4lku is ON HOLD Authors: Walton, T. A., Rees, D. C. Description: Structure of the C-terminal domain of the E. coli mechanosensitive channel of larg... |
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==Structure of the C-terminal domain of the E. coli mechanosensitive channel of large conductance== | |||
<StructureSection load='4lku' size='340' side='right'caption='[[4lku]], [[Resolution|resolution]] 1.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4lku]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_DH1 Escherichia coli DH1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LKU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lku OCA], [https://pdbe.org/4lku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lku RCSB], [https://www.ebi.ac.uk/pdbsum/4lku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lku ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MSCL_ECOLI MSCL_ECOLI] Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 4 nanosiemens. Participates in the regulation of osmotic pressure changes within the cell. Opens at a pressure just below that which would cause cell disruption and death. The force required to trigger channel opening depends on the membrane lipids composition.<ref>PMID:10202137</ref> <ref>PMID:23416054</ref> <ref>PMID:23875651</ref> <ref>PMID:7511799</ref> <ref>PMID:9632260</ref> | |||
==See Also== | |||
*[[Ion channels 3D structures|Ion channels 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli DH1]] | |||
[[Category: Large Structures]] | |||
[[Category: Rees DC]] | |||
[[Category: Walton TA]] | |||
Latest revision as of 12:20, 1 March 2024
Structure of the C-terminal domain of the E. coli mechanosensitive channel of large conductance
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